18 Full details of original trials ethics and regulatory approval, alongside full inclusion criteria are accessible at (13)60986-1/fulltext. Participants came from STICH II-an international, prospective, multicenter, randomized trial of early surgery versus initial conservative therapy for lobar ICH at 78 sites across 27 countries. 9 – 11, 17 We, therefore, set out to describe the agreement of the methods available to quantify ICH volume, in comparison with a reference standard semiautomatic method (which makes no assumptions about the shape of the hematoma) for calculating ICH volume in these groups from the STICH II 18 cohort. Studies have validated the following adjustments: ABC/2.4, 13 ABC/3, 16 and 2/3SC (where S=the area of largest hemorrhage on axial slice methods). ICH at randomization in the STICH II trial (Early Surgery Versus Initial Conservative Treatment in Patients With Spontaneous Supratentorial Lobar Intracerebral Haematomas) 3 Although the ABC/2 formula has been validated for small-to-moderately sized elliptical hemorrhages, 7, 8 there is still debate about the validity of the ABC/2 method in quantifying ICH in the following groups 9 – 17: 3 In the formula, A=the longest diameter of hemorrhage on the largest slice of hematoma, B=the longest perpendicular diameter to A, and C=the depth of hematoma (calculated as the number of slices with hemorrhage multiplied by slice thickness).
3 The ABC/2 method approximates ICH volume to the volume of an ellipsoid (4/3 πr 3). Multiple methods exist currently to perform this task, with the ABC/2 method being the most validated. 5, 6 Paramount to this work is having an accurate and expedient method for quantifying ICH volume from patient’s neuroimaging. Moreover, ICH volume at ictus is an outcome measure and safety criterion for current clinical trials that are hoped to improve patient outcomes in future (MISTIE III, NCT01827046). 2 Initial hemorrhage volume has been well documented as one of the variables for predicting patient outcome 3 and included in the ICH score 4 for predicting patient mortality. Spontaneous intracerebral hemorrhage (ICH) has a >40% mortality at 30 days, 1 and most survivors are left disabled. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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